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KMID : 0370220030470060456
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Yakhak Hoeji
2003 Volume.47 No. 6 p.456 ~ p.460
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β-Lactamase Inhibitory Activity and Comparative Activity of 6-Exomethylenepenam Derivatives Combined with β-Lactam Antibiotics
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임채욱/Im CU
박희석/정미량/강주성/임철부/Park HS/Chung ML/Kang JS/Yim CB
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Abstract
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In vitro β-lactamase inhibitory activity of 6-exomethylenepenam compounds (1,2,3,4 and 5) was compared with clavulanic acid, sulbactam and tazobactam. The inhibitory a ctivity of compound 3 was stronger than those of sulbactam and clavulanic acid against Type I and II enzymes and stronger than tazobactam against Type III, IV, TEM enzymes. The inhibitory activity of 5 was stronger than sulbactam and clavulanic acid against Type I and II enzymes and stronger than tazobactam against Type III and IV enzymes. The in vitro antimicrobial activity of 3,4 and 5 combined with ampicillin and cefoperazone was compared with the sulbactam against β-lactamase producing 27 strains. But, synergistic activity of 3 and 5 was inferior to tazobactam.
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KEYWORD
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